RESUMO
Coronavirus disease 2019 (COVID-19) has resulted in a global pandemic, and there is limited data on effective therapies. Bacillus Calmette-Guérin (BCG) vaccine, a live-attenuated strain derived from an isolate of Mycobacterium bovis and originally designed to prevent tuberculosis, has shown some efficacy against infection with unrelated pathogens. In this study, we reviewed 120 consecutive adult patients (≥18 years old) with COVID-19 at a major federally qualified health centre in Rhode Island, United States from 19 March to 29 April 2020. Median age was 39.5 years (interquartile range, 27.0-50.0), 30% were male and 87.5% were Latino/Hispanics. Eighty-two (68.3%) patients had BCG vaccination. Individuals with BCG vaccination were less likely to require hospital admission during the disease course (3.7% vs. 15.8%, P = 0.019). This association remained unchanged after adjusting for demographics and comorbidities (P = 0.017) using multivariate regression analysis. The finding from our study suggests the potential of BCG in preventing more severe COVID-19.
Assuntos
Vacina BCG/imunologia , Infecções por Coronavirus/imunologia , Pneumonia Viral/imunologia , Adulto , COVID-19 , Infecções por Coronavirus/epidemiologia , Feminino , Hispânico ou Latino , Humanos , Masculino , Pandemias , Pneumonia Viral/epidemiologia , Rhode Island/epidemiologia , Índice de Gravidade de DoençaRESUMO
The occupational pathogenesis of chlorine in exposed workers are described and compared with the classic pathogenesis. The exposed group consisted of 82 men with occupational exposure to chlorine.The control group consisted of 46 men who were not exposed, all of them works in the same cellulose processing factory. The exposed group had the symptoms of theclassical pathogenesis to a highly significant degree (p<0,0001) compared to the unexposed control group. We found a number of symptoms signs, disorders and syndromes which are not described in the classical pathogenesis, including: diminished tolerance to alcohol, back pain, pains in the joints dependent on weather conditions, dependent oedema, diminished taste sensitivity, persistent chronic hepatitis, hepatic steatofibrosis, chronic obstructive airways disease, polycythaemia with haemosiderosis and chronic conjunctivitis. The intensity of symptoms and signs was in direct proportion to the duration of exposure to chlorine
